IONS

Ionis Pharmaceuticals, Inc. $44.90 as of 2026-10-28
Model view — historical tendencies for the days ahead, not a forecast
Next 1 day
-0.1%
Next 1 week
+1.1%
Next 1 month
+1.6%
Seasonality
Bullish window historically
Next 30 days (to Nov 28): +5.1% median, 65% of the last 34 years finished up.
20-year seasonality chart →
Mean reversion
Overbought — RSI(2) at 88
RSI(2) under 15 is oversold (this name has historically bounced); over 85 is overbought. Its dip-buy edge in history is -0.12%/day.
Mean-reversion stats →
1-month breakdown — Market · β 0.51 +1.3% · Seasonal tilt +0.3%
$120M/day volume 43% volatility -38% 1-year -48% from ATH
52-week range · 6% of the way up · -48% from the high
$42.08$86.74

Congressional trades in IONS Full tracker →

4 members · 5 buys / 4 sells · $37K–$205K disclosed · latest filing Apr 17, 2023.

SELL DG Daniel Goldman · traded Mar 6, 2023 $1K–$15K
BUY DS Donna Shalala · traded May 8, 2019 $1K–$15K
SELL DS Donna Shalala · traded Jun 24, 2019 $1K–$15K
BUY TM Thomas MacArthur · traded Nov 2, 2016 $1K–$15K
BUY TM Thomas MacArthur · traded Nov 2, 2016 $15K–$50K
SELL TM Thomas MacArthur · traded Feb 2, 2016 $15K–$50K
BUY TM Thomas MacArthur · traded Feb 12, 2016 $1K–$15K
BUY TM Thomas MacArthur · traded Feb 24, 2016 $1K–$15K
SELL SW Sheldon Whitehouse · traded Jan 20, 2016 $1K–$15K

Earnings Full history →

Next report 2026-11-04 (Wednesday, before open, in 6 days) · EPS est. -0.93.

1-day std dev
5.7%
Finished up
53%
Biggest pop
+22.0%
Biggest drop
-10.2%

Standard deviation of the close-to-close move over the last 60 reports. History, not a forecast.

ReportedEst.Actual SurpriseGap Day 1Day 5
2026-07-29 beat -0.88 -0.42 +51.7% -0.4% -2.3% -2.0%
2026-04-29 beat -0.77 -0.30 +60.9% +0.4% +4.2% +7.1%
2026-02-25 beat -1.22 -1.15 +5.6% -4.3% -5.3% -7.0%
2025-10-29 beat -1.05 -0.61 +41.8% -1.6% -2.3% +1.5%
2025-07-30 beat 0.16 0.85 +415.1% +8.4% +4.6% -1.9%
2025-04-30 beat -1.03 -0.92 +10.4% +6.6% +3.0% +10.9%
2025-02-19 beat -0.84 -0.43 +49.0% +8.0% -0.4% -0.6%
2024-11-06 beat -0.98 -0.72 +26.1% +3.0% +0.6% -2.6%
2024-08-01 beat -0.76 -0.24 +68.6% +0.8% +3.8% -3.9%
2024-05-07 beat -0.81 -0.77 +5.4% -3.1% -3.2% -9.5%
2024-02-21 beat -0.75 0.12 +115.8% +3.5% -1.8% +4.9%
2023-11-02 beat -0.89 -0.85 +4.8% +1.7% -3.4% +4.5%
2023-08-09 beat -0.70 -0.41 +42.5% +4.0% +1.1% +0.0%
2023-05-03 beat -0.76 -0.68 +10.4% +1.9% -2.2% +0.9%
2023-02-22 miss -0.86 -1.18 -37.5% +0.2% -3.7% -6.0%
2022-11-09 beat -0.53 -0.16 +69.7% +0.7% +1.9% +1.0%
2022-08-09 miss -0.47 -0.56 -20.1% -1.2% -3.2% -3.0%
2022-05-04 beat -0.52 -0.27 +47.1% +0.6% +2.8% -14.2%
2022-02-24 beat 0.31 1.55 +393.5% -3.0% +5.7% +8.2%
2021-11-03 miss -0.32 -0.34 -5.3% -0.2% +2.4% +1.0%
2021-08-04 beat -0.32 -0.26 +19.0% -0.6% +0.0% +1.1%
2021-05-05 miss -0.25 -0.32 -25.6% +0.2% -5.0% -11.1%
2021-02-24 beat 0.30 0.44 +48.8% +0.9% +0.3% -5.8%
2020-11-04 miss -0.16 -0.22 -37.5% -0.4% +1.3% +4.7%
2020-08-05 beat -0.28 -0.23 +17.9% +1.0% -3.0% -10.6%
2020-05-06 miss -0.11 -0.35 -204.3% -3.2% -2.1% -5.7%
2020-02-26 beat 1.03 1.33 +29.2% +3.0% +1.3% -1.3%
2019-11-06 beat -0.32 0.18 +155.9% +3.1% +2.2% +6.0%
2019-08-07 beat -0.20 -0.01 +95.0% +3.0% +5.6% +4.5%
2019-05-09 miss 0.78 0.62 -20.5% -0.9% -1.9% -1.3%
2019-02-27 beat — 0.20 +19707.8% +1.5% +15.1% +12.3%
2018-11-06 beat -0.17 -0.03 +82.5% +0.9% +4.1% +0.4%
2018-08-07 miss -0.19 -0.29 -56.4% -1.5% +1.3% +16.9%
2018-05-04 beat -0.15 -0.01 +93.5% +1.4% +6.6% +11.3%
2018-02-27 beat -0.04 0.02 +150.0% -2.7% +0.2% +0.5%
2017-11-07 beat -0.08 — +100.0% -4.1% -3.6% -1.3%
2017-08-08 miss -0.06 -0.09 -57.8% -1.6% -8.1% -11.5%
2017-05-09 beat -0.31 0.03 +109.5% +5.3% +3.3% -0.8%
2017-02-28 beat -0.11 0.24 +310.1% +4.4% +6.1% -0.8%
2016-11-09 beat 0.04 0.06 +38.9% +4.5% +22.0% +44.9%
2016-08-09 beat -0.52 -0.47 +9.6% +2.1% +1.2% -5.4%
2016-05-04 beat -0.54 -0.52 +3.7% +0.3% -7.8% -13.8%
2016-02-25 miss -0.54 -0.59 -8.4% -0.4% -4.4% +9.3%
2015-11-09 beat -0.33 -0.30 +8.3% -3.4% +12.4% +7.9%
2015-08-04 beat 0.29 0.29 +1.2% +0.4% +2.5% -6.4%
2015-05-05 beat -0.20 -0.14 +31.2% +4.1% -2.2% +3.8%
2015-02-27 beat 0.04 0.16 +325.2% +0.7% +1.8% +4.6%
2014-11-07 miss -0.20 -0.23 -12.2% -2.8% -1.5% +8.3%
2014-08-04 beat -0.11 -0.10 +11.1% +0.7% +3.4% +14.4%
2014-05-06 beat -0.28 -0.27 +4.4% -2.3% -3.7% -2.0%
2014-02-28 miss -0.18 -0.21 -13.5% +1.2% -9.5% -9.1%
2013-11-05 beat -0.30 -0.21 +29.7% +1.1% -2.8% -2.8%
2013-08-06 beat -0.25 -0.10 +60.8% -0.1% -3.1% -7.5%
2013-05-07 miss -0.02 -0.03 -68.8% -2.1% -10.2% -5.6%
2013-02-28 beat -0.19 -0.03 +83.9% +0.0% +3.3% +24.2%
2012-11-06 miss -0.29 -0.37 -28.7% -3.0% -7.2% -0.9%
2012-08-06 beat -0.08 -0.01 +87.7% +0.2% +9.2% +8.4%
2012-05-08 beat -0.28 -0.24 +14.9% -0.4% +2.6% +13.3%
2012-02-29 miss -0.13 -0.20 -56.2% +2.2% +5.8% -3.3%
2011-11-07 miss -0.20 -0.27 -32.0% -8.3% -9.1% -15.0%

Not investment advice.